By State
Best Fertility Clinics in Missouri: Compare IVF Success Rates, Costs and Services
The best fertility clinics in Missouri for intended parents are the ones that fit their treatment needs and family-building plans.
IVF success rates are part of the comparison, along with laboratory quality, available treatments and experience working with gestational surrogates.
This guide compares four Missouri fertility clinics using standardized reporting from the Society for Assisted Reproductive Technology (SART), including the 2024 clinic data provided for this guide.
The data can help you compare IVF outcomes while the clinic profiles show which services may be relevant if your plans include donor treatment, genetic testing or gestational surrogacy.
Fertility Clinics in Missouri
SART is a professional organization for assisted reproductive technology providers. Its fertility clinic reporting system provides standardized information about member clinics and their treatment outcomes, giving intended parents a consistent source for comparing fertility programs.
SART is affiliated with the American Society for Reproductive Medicine (ASRM), while laboratory accreditation is handled separately.
When comparing clinics, look at SART membership and reported outcomes alongside the accreditation of the embryology laboratory rather than treating any one designation as a complete measure of quality.
The Missouri clinics featured in this guide are:
- Reproductive Health & Fertility Center (Columbia)
- Mid-Missouri Reproductive Medicine and Surgery (Columbia)
- STL Fertility in Creve Coeur (Creve Coeur)
- Fertility and Reproductive Medicine (St. Louis)
All four clinics list donor egg services in the supplied SART data.
If gestational surrogacy is part of your plan, confirm the clinic’s current gestational-carrier program and requirements during your consultation.
Your fertility clinic will eventually review your surrogate’s medical records, complete its required medical screening and perform the embryo transfer.
The clinics featured in this guide are SART member clinics with laboratory accreditation through the College of American Pathologists (CAP) or The Joint Commission. Unless otherwise noted, success-rate data is based on SART’s 2024 clinic data.
Reproductive Health & Fertility Center
Location: Department of Obstetrics, Gynecology and Women’s Health, Suite 203, Columbia, MO 65201
Phone: 573-817-3101
Reproductive Health & Fertility Center is part of the University of Missouri’s Department of Obstetrics, Gynecology and Women’s Health in Columbia.
For intended parents in central Missouri, its location can reduce the amount of driving required for IVF monitoring and procedures.
Services offered:
- Donor Egg
- Donor Embryo
- Egg Cryopreservation
- Embryo Cryopreservation
- Female Couple
- HIV Patients
- Male Couple
- Mental Health
- Outside Monitoring
- PGT
- Single Men
- Single Women
Success Rates for Frozen Embryo Transfer With PGT-A
| Age at Egg Retrieval | Under 35 | 35–37 | 38–40 | 41–42 | Over 42 |
| Live Birth Per Single Embryo Transfer | 1/1 | 0/0 | 0/0 | 0/1 | 0/0 |
Success Rates for Frozen Embryo Transfer Without PGT-A
| Age at Egg Retrieval | Under 35 | 35–37 | 38–40 | 41–42 | Over 42 |
| Live Birth Per Single Embryo Transfer | 1/4 | 1/2 | 0/2 | 0/1 | 0/0 |
The number of transfers in these categories is small.
A result of 1/1 means one transfer resulted in one live birth. With so few cases, the result can change considerably after only a few additional transfers.
Mid-Missouri Reproductive Medicine and Surgery, Inc.
Location: 1506 E. Broadway, Suite 220, Columbia, MO 65201
Phone: (573) 443-4511
Mid-Missouri Reproductive Medicine and Surgery is another Columbia fertility clinic.
Central Missouri intended parents can compare two local programs before deciding whether the services available farther east warrant additional travel.
Services offered:
- Donor Egg
- Donor Embryo
- Egg Cryopreservation
- Embryo Cryopreservation
- Female Couple
- HIV Patients
- Male Couple
- Outside Monitoring
- PGT
- Single Men
- Single Women
Success Rates for Frozen Embryo Transfer With PGT-A
| Age at Egg Retrieval | Under 35 | 35–37 | 38–40 | 41–42 | Over 42 |
| Live Birth Per Single Embryo Transfer | 44.4% | 42.9% | 7/19 | 1/2 | 0/0 |
Success Rates for Frozen Embryo Transfer Without PGT-A
| Age at Egg Retrieval | Under 35 | 35–37 | 38–40 | 41–42 | Over 42 |
| Live Birth Per Single Embryo Transfer | 3/7 | 1/4 | 3/4 | 0/0 | 0/0 |
Where SART reports a fraction, you can see how many transfers produced live births.
Three live births from four transfers, for example, provide different context than a similar percentage calculated from dozens of transfers.
STL Fertility, LLC
Location: 555 N. New Ballas Road, Suite 150, Creve Coeur, MO 63141
Phone: 314-983-9000
STL Fertility is in Creve Coeur in the St. Louis metro.
Intended parents in eastern Missouri have relatively easy access to the clinic, while those coming from other parts of the state should ask which monitoring appointments can be completed closer to home.
Services offered:
- Donor Egg
- Donor Embryo
- Egg Cryopreservation
- Embryo Cryopreservation
- Female Couple
- HIV Patients
- Male Couple
- Outside Monitoring
- PGT
- Single Men
- Single Women
Success Rates for Frozen Embryo Transfer With PGT-A
| Age at Egg Retrieval | Under 35 | 35–37 | 38–40 | 41–42 | Over 42 |
| Live Birth Per Single Embryo Transfer | 42.3% | 43.4% | 40.7% | 36.4% | 1/3 |
Success Rates for Frozen Embryo Transfer Without PGT-A
| Age at Egg Retrieval | Under 35 | 35–37 | 38–40 | 41–42 | Over 42 |
| Live Birth Per Single Embryo Transfer | 38.2% | 5/8 | 2/10 | 0/1 | 0/0 |
If you’re planning to use a gestational surrogate, ask how many gestational carrier transfers the clinic performs each year and what medical screening it requires.
Those policies determine what your surrogate needs to complete before the clinic clears her for transfer.
Fertility and Reproductive Medicine Center
Location: 4444 Forest Park Ave., Suite 3100, St. Louis, MO 63108
Phone: 314-286-2400
Fertility and Reproductive Medicine Center is Washington University’s fertility program in St. Louis.
Services offered:
- Donor Egg
- Donor Embryo
- Egg Cryopreservation
- Embryo Cryopreservation
- Female Couple
- HIV Patients
- Male Couple
- Mental Health
- Outside Monitoring
- Ovarian Tissue Cryopreservation
- PGT
- Single Men
- Single Women
Success Rates for Frozen Embryo Transfer With PGT-A
| Age at Egg Retrieval | Under 35 | 35–37 | 38–40 | 41–42 | Over 42 |
| Live Birth Per Single Embryo Transfer | 67.2% | 71.4% | 65.9% | 2/11 | 2/3 |
Success Rates for Frozen Embryo Transfer Without PGT-A
| Age at Egg Retrieval | Under 35 | 35–37 | 38–40 | 41–42 | Over 42 |
| Live Birth Per Single Embryo Transfer | 48.4% | 39.3% | 29.7% | 2/5 | 2/6 |
These figures are most useful when you consider how many transfers sit behind each result and which patients were treated.
Patient characteristics and treatment practices can differ between programs, so clinic percentages aren’t a straightforward ranking.
How to Compare Fertility Clinic Success Rates
Compare fertility clinic success rates by looking at live birth results for patients whose age, egg source and treatment are similar to yours. SART’s guide to success rates explains why differences in patients and treatment can affect clinic statistics..
Focus on live birth rates rather than pregnancy rates, then check how many transfers are behind each result.
Age, egg source, embryo testing, diagnosis and treatment protocol can all affect which data is most relevant to you.
During a consultation, ask for the clinic’s live birth outcomes for patients with circumstances similar to yours. That comparison is more useful than choosing a clinic based on its highest published percentage.
Understanding the IVF Process
IVF involves retrieving eggs, fertilizing them with sperm in a laboratory and transferring a resulting embryo to the uterus. Cleveland Clinic’s overview of IVF treatment provides additional detail on the medical steps involved.
In gestational surrogacy, the embryo is transferred to the gestational surrogate rather than an intended parent.
The process generally includes:
- Fertility evaluation: Your clinic reviews your medical and reproductive history and orders testing based on your treatment needs.
- Ovarian stimulation: Fertility medications encourage multiple eggs to mature. Bloodwork and ultrasound allow the clinic to monitor the response.
- Egg retrieval: Mature eggs are collected from the ovaries during a medical procedure.
- Fertilization and embryo development: Eggs are fertilized with sperm in the embryology laboratory, where the resulting embryos are monitored as they develop.
- Optional preimplantation genetic testing: Depending on your circumstances, embryos may undergo PGT-A, PGT-M or another form of testing before transfer.
- Embryo cryopreservation: Embryos can be frozen and stored for future transfer.
Embryo cryopreservation is particularly relevant to surrogacy. Intended parents can create and freeze embryos before matching with a gestational surrogate.
Once there is a match, the fertility clinic can review the surrogate’s medical history, complete its screening and prepare her for a frozen embryo transfer.
Average IVF Costs in Missouri
IVF costs in Missouri vary by clinic, medication needs and which services are included in the treatment plan, ranging anywhere from $12,000-$25,000.
A Missouri-specific IVF cost overview provides additional context for comparing treatment expenses, while an itemized estimate from the clinic shows what your own treatment plan will cost.
Common expenses include:
| IVF Expense | What Affects the Cost |
| Egg retrieval | Procedure, anesthesia and facility charges |
| Medications | Medication type, dosage and length of stimulation |
| Laboratory process fees | Fertilization method, embryo culture and laboratory services |
| Embryo freezing | Clinic and laboratory pricing |
| PGT-A, if used | Embryo biopsy and genetic laboratory charges |
| Donor eggs, if needed | Donor source and whether eggs are fresh or frozen |
| Donor sperm, if needed | Sperm bank, specimen and shipping charges |
| Storage | Length of storage and annual fees |
| Embryo transfer | Monitoring, medication and transfer charges |
Ask whether a clinic’s IVF quote includes anesthesia, ICSI, embryo freezing, storage, PGT biopsy, outside genetic laboratory charges and frozen embryo transfer.
These details make it easier to compare what you’d actually pay rather than comparing base prices that include different services.
Insurance coverage can also change your out-of-pocket cost. Missouri doesn’t have a broad state mandate requiring health plans to cover IVF, but employer and individual benefits vary.
Your policy may provide benefits for diagnostic testing, medication or other fertility services even if it doesn’t cover the full IVF cycle.
Confirm your benefits with your insurer and ask the fertility clinic which services may be billed separately.
Questions to Ask Before Choosing a Fertility Clinic
Before choosing a fertility clinic, ask questions that show how the clinic would handle your treatment, what you’re likely to pay and how it works with gestational surrogates if surrogacy is part of your plan.
- What is your live birth rate for my age group and treatment circumstances? This gives you a more relevant comparison than an overall clinic percentage.
- How many IVF cycles do you perform each year? Treatment volume puts published success rates in context.
- How often do you perform gestational carrier transfers? The answer tells you how regularly the clinic handles surrogate cycles.
- Do you have an on-site embryology lab? Ask where fertilization, embryo culture, biopsy, freezing and storage take place.
- Which optional treatments would increase my costs? Ask which services the physician recommends for your case and what each one costs.
- What happens if my first IVF cycle isn’t successful? Ask how the physician reviews the cycle and decides whether the treatment protocol should change.
- What are your medical requirements for gestational surrogates? These requirements can affect which surrogate candidates receive final medical clearance.
- Can I complete monitoring closer to home? This can be especially useful for families traveling to Columbia or St. Louis from another part of Missouri.
The answers will give you a clearer picture of how each clinic fits your medical needs, budget and surrogacy plans.
How Fertility Clinics Work with Surrogacy Agencies
Fertility clinics provide the reproductive medical care involved in gestational surrogacy, while surrogacy agencies coordinate nonmedical parts of an agency-assisted journey.
This agency and clinic comparison explains the separate responsibilities these professionals typically handle.
After embryos have been created, an agency-assisted journey generally follows this sequence:
- Choose a gestational surrogate. You and a prospective surrogate decide whether to match through the agency’s matching process.
- The fertility clinic reviews the surrogate’s medical records. The clinic checks her pregnancy and medical history against its gestational carrier requirements.
- The surrogate travels to your fertility clinic for an in-person medical clearance appointment. The clinic performs the testing it requires before approving her for embryo transfer.
- Legal contracts are completed. The intended parents and surrogate work with separate attorneys to complete the Gestational Carrier Agreement before transfer medications and procedures move forward as required.
- The fertility clinic performs the embryo transfer. The surrogate follows the clinic’s medication and monitoring protocol and returns to the clinic for transfer.
- The clinic handles early pregnancy monitoring. After the appropriate early monitoring period, the surrogate transitions to her obstetric provider for prenatal care.
Your surrogate doesn’t have to live near your Missouri fertility clinic. If she lives elsewhere in Missouri or in another state, she can travel to the clinic for required screening and transfer appointments.
In an agency-assisted program, the agency typically coordinates required surrogate travel.
Intended parents cover eligible surrogate travel expenses according to the agency program and Gestational Carrier Agreement, so the fertility clinic’s location can affect the schedule and travel budget.
The fertility clinic makes the final medical-clearance decision.
Agency screening can identify candidates who appear to meet common gestational carrier standards, but your reproductive endocrinologist determines whether a particular surrogate is medically approved for transfer.
Talk With a Surrogacy Professional About Choosing the Right Fertility Clinic
Choosing among the best fertility clinics in Missouri means finding a clinic that fits your medical needs and the family-building plan you’re considering.
Compare live birth results for patients with circumstances similar to yours, treatment volume, laboratory accreditation, available services, total treatment costs and experience with gestational carrier transfers.
Location belongs in that comparison as well, particularly when treatment requires repeated trips to Columbia or the St. Louis area.
For intended parents in Kansas City, Springfield and rural Missouri, ask whether routine monitoring can take place closer to home and which appointments require travel to the fertility clinic.
If you’re considering surrogacy, also ask what your future surrogate will need to complete at that clinic.
If gestational surrogacy may be part of your plans, talk with a surrogacy professional about how your fertility clinic’s requirements fit with surrogate matching, screening, travel and embryo transfer.
Ready to get started? Contact a surrogacy agency now to get free information.